10 Can single-step genome-wide association analysis (ssGWAA) account for population structure?
نویسندگان
چکیده
منابع مشابه
Genome-wide association analysis
Genome-wide association (GWA) studies have become overwhelmingly popular in the last few years as a means to elucidate associations between particular alleles in one’s DNA and a predisposition to disease, using genetic data from unrelated individuals randomly sampled from a population (Balding, 2006; WTCCC, 2007). The recent availability of large amounts of such population genetic data necessit...
متن کاملA Population Structure and Genome-Wide Association Analysis on the USDA Soybean Germplasm Collection
Population structure analyses and genome-wide association studies (GWAS) conducted on crop germplasm collections provide valuable information on the frequency and distribution of alleles governing economically important traits. The value of these analyses is substantially enhanced when the accession numbers can be increased from ~1,000 to ~10,000 or more. In this research, we conducted the firs...
متن کاملStatistical analysis for genome-wide association study
In the past few years, genome-wide association study (GWAS) has made great successes in identifying genetic susceptibility loci underlying many complex diseases and traits. The findings provide important genetic insights into understanding pathogenesis of diseases. In this paper, we present an overview of widely used approaches and strategies for analysis of GWAS, offered a general consideratio...
متن کاملReplicability analysis for genome-wide association studies
The paramount importance of replicating associations is well recognized in the genomewide associaton (GWA) research community, yet methods for assessing replicability of associations are scarce. Published GWA studies often combine separately the results of primary studies and of the follow-up studies. Informally, reporting the two separate meta-analyses, that of the primary studies and follow-u...
متن کاملGenome-Wide Analysis of Single Nucleotide Polymorphisms Uncovers Population Structure in Northern Europe
BACKGROUND Genome-wide data provide a powerful tool for inferring patterns of genetic variation and structure of human populations. PRINCIPAL FINDINGS In this study, we analysed almost 250,000 SNPs from a total of 945 samples from Eastern and Western Finland, Sweden, Northern Germany and Great Britain complemented with HapMap data. Small but statistically significant differences were observed...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Animal Science
سال: 2020
ISSN: 0021-8812,1525-3163
DOI: 10.1093/jas/skaa278.018